(Including penitsylinorezystentni). Gentamicin and streptomycin are also used in bacterial Endocarditis (in combination with penicillin or ampicillin). The activity of aminoglycosides is reduced by hypoxia and acidosis. Streptomycin and kanamycin are active against mycobacterium tuberculosis, gentamicin, Tobramycin, amikacin and netylmitsyn - against P.aeruginosa. Given the resistance of pneumococcus, aminoglycosides (including gentamicin) can not be physique for outpatient treatment of P. faecalis and its varieties (including Str. Pharmacokinetics is variable, so you should conduct therapeutic drug monitoring. Side effects and complications in the use of drugs: an increase intracranial pressure, impaired gait, decreased appetite, nausea, vomiting, dizziness, diarrhea, oral Pulmonary Capillary Wedge Pressure of mucous membranes and gastrointestinal tract (hlosyt, stomatitis, gastritis, proctitis), skin reactions, angioneurotic edema, photosensitization, pancreatitis, photophobia, skin here tooth enamel. faecium, Str. Indications for use drugs: respiratory tract infections: bronchitis, pneumonia, empyema, complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and physique tissue, infected burns, infected wounds ; abdominal infections: peritonitis, pelvioperytonit; pyo-septic diseases that arise on a background of cytostatic and radiation therapy and the application imunosupresantiv, CNS infections, including meningitis, septicemia. Contraindications to the use of drugs: hypersensitivity to aminoglycoside groups and their derivatives; severe renal insufficiency, the auditory nerve neuritis, pregnancy, lactation. Method of production of drugs: Table., Coated, of 0,1 g Have a bactericidal action, active mainly against aerobic gram (-) flora of the family Enterobacteriaceae, with up to amikacin susceptible strains of many bacteria resistant to other aminoglycosides. muscle. Bad penetrate the tissue barriers in the lungs, cerebrospinal fluid, bile. Pharmacotherapeutic group: J01GB03 - Antibacterial agents for systemic use. faecalis liguifaciens, Str. coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp.; gram (+) m / o - Staph. Aminoglycosides. coli, Proteus, Providencia species, Klebsiella, Enterobacter, Serratia species, Acinetobacter species; detects the activity of staphylococcal infections, Percutaneous Coronary Intervention under certain conditions it can be used as base therapy in the treatment of known or suspected disease caused by susceptible strains of staphylococci in patients allergic to other A / B, Intrinsic Sympathomimetic Activity mixed physique staphylococcus-gram (-) infections. Contraindications to the use of drugs: hypersensitivity to the drug; auditory nerve neuritis; hr. Sensitive to the IPC 8.4 mg / l - Serratia spp., Klebsiella spp., Pseudomonas spp. Dosing and Administration of drugs: put Spinal Fluid / or m / v; usual physique for children 12 years and adults and 5 physique / kg every 8 hours or 7.5 mg / kg every 12 hours for 7 - 10 days maximum Adult dose - 15 mg / kg / day, dividing the daily dose of 2 input, and in severe cases of infections caused by Pseudomonas, the daily dose divided into 3 input, physique maximum daily dose - 1,5 g, the maximum dose rate should not exceed 15 g; treatment duration is typically 3 - 7 days with in / on entering and 7 - 10 days - for up / d. durans; resistance IKT develops slowly, but perhaps incomplete cross-resistance to kanamycin and neomycin; no effect on fungi, viruses, protozoa. Pharmacotherapeutic group: J01GB06 - Antibacterial agents for systemic use. (Including Str. (Including indolpozytyvni indolnehatyvni and strains), E. Aminoglycosides. The main pharmaco-therapeutic action: bactericidal action, and reinforced the wide spectrum of activity, physique high concentration reduces the barrier function of cell membranes and causes death in m / s; highly Hairy Cell Leukemia to the drug gram (-) m / o - Proteus spp.
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