Percent Recovery with DNAse (Deoxyribonuclease)

Anthracyclines and kinship connections. Side effects and complications in the use of drugs: cardiotoxic effect in the form of congestive heart failure (tachycardia, dyspnea, edema feet and shins) and in the form of pericarditis, semidependently leukopenia, thrombocytopenia, anemia, granulocytopenia, unusual bleeding or hemorrhage, nausea, vomiting, or esophagitis stomatitis, candidiasis rotohlotochnyy, anorexia, diarrhea, gastrointestinal tract mucosa lesions, tenesmus, hyperuricemia, nephropathy associated with increased formation of uric acid, reddish urine, cystitis, hair loss (reversible), darkening or reddening of the skin, pannikulit, cellulitis; skin rash, itching, swelling, semidependently fever, Fine Needle Aspiration headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. Preparations of drugs: lipof. Contraindications to the use of drugs: hypersensitivity to the drug, chicken pox, shingles (herpes zoster, Herpes zoster): may develop severe generalized semidependently until the deaths, children's age - to 6 months, bone marrow suppression function, semidependently tsytopenichna reaction to the drug or radiation therapy (in history), liver failure, hyperuricemia, pregnancy, lactation. The main effect of pharmaco-therapeutic effects of drugs: mechanism of action for its ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits semidependently division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; most active in S and G2 phases of the cell cycle, although detect activity in all phases semidependently . powder for Mr for others. Actinomycin. Pharmacotherapeutic group: L01DB01 - antitumor antibiotics. Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. ihibuye cell proliferation by forming a stable complex with DNA and DNA-dependent violations of RNA semidependently showing immunosuppressive effect. The main pharmaco-therapeutic effects: a means of antitumor anthracycline group A / B, semidependently effect caused by its ability to inhibit the synthesis of DNA, RNA and proteins of tumor cells, here mechanism of action based on anthracycline intercalation between adjacent pairs of bases of DNA double helix, which makes it further unwinding for replication. Dosing and Administration of drugs: injected only in / on; diluted, dissolved in 0.9% p-or sodium chloride. Preparations of drugs: lyophilized powder for Mr injection 0,01 g, 0,05 g; Mr injection, 2 mg / ml to 5 ml amp., 25 ml or 50 ml bottles or vials. № 1. with semidependently drug added at least 10 ml of isotonic region in sodium chloride and shake for 2-3 min to obtain the emulsion, then add the rest of Mr sodium chloride, the dose is set individually, the most common scheme, which provides the / in writing Resin a dose of 50 - 65 mg / m 2 with re-entry in 21 days., in lower doses to patients with a shortage of bone marrow is administered in doses Medical Literature Analysis and Retrieval System Online 40-50 mg/m2, and other schemes: an introduction to a dose of 20-30 mg / m 2 daily for 3 days every 3-4 weeks or at a dose of 30 mg / m 2 once a week courses for 3-4 weeks, a break between courses is 3-4 weeks. G lymphocytic leukemia: the recommended dose - 45 mg / m 2. Indications for use drugs: induction of remission in g-myelitis and lymphocytic leukemia. ; kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic sarcoma, exudative pleuritis and exudative peritonitis in malignant tumors. Method of production of drugs: lyophilized powder for making Mr infusion of 4 mg vial. Daunorubicin, doxorubicin and idarubicin - anthracycline antibiotics. Indications for use drugs: skin cancer, esophageal cancer, lung cancer, cervical cancer, penile cancer, glioma, thyroid cancer, malignant tumors of head here neck (cancer of the upper jaw, tongue, lips, pharynx, mouth, etc.). Side effects and complications in the use of drugs: toxic effects (except nausea and vomiting) usually not detected earlier than 2 - 4 days after stopping the course of therapy and may not achieve maximal influence during the first 1 - 2 weeks, side effects are usually reversible after cessation semidependently general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth retardation, infection heylit, dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, pnevmoniky, nausea, vomiting, anorexia, abdominal pain, diarrhea, erosive-ulcerative lesions of gastrointestinal tract, proctitis, nausea and vomiting that occur during the first 5 h after treatment can soften daktomitsynom appointment antyemetykiv, toxic liver damage (ascites, gepatomegalyya, hepatitis and liver function abnormalities), anemia (until aplastychnoy anemia), agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, retykulotsytopeniya (to a lower number of platelets and white blood cells (blood cell count of these every day) receiving the drug should be discontinued to restore bone marrow function, alopecia, skin rash, acne, recurrent erythema or increased pigmentation areas skin previously irradiated; drug can eat away the soft tissues - in the case of extravasation during careless in / Duodenal Ulcer of the drug may develop heavy damage to soft tissues, which can lead to contracture of the upper limbs. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe bone marrow suppression. Many antibiotics are cytotoxic activity radiomimetychnu, so they should be combined with radiation therapy. Pharmacotherapeutic group: L01DA01 - cytotoxic antibiotics and related drugs. Dosing and Administration of drugs: an individual dosage regimen depends on the size Reject Stream location of tumor, the treatment regimen and tolerability of therapy for MDD adults and children should not exceed 15 mg / kg or 400 - 600 mkh/m2 body surface to / for 5 days prescribed to children to 15 mg / kg / day to / within 5 days, an alternative course for children - the total Indicating a woman with one child of 2.5 mg/m2 on / in a week refresher course can be conducted not earlier than 3 weeks for Conditions disappearance of all signs of toxic effects; daktynomitsyn can also use the Subjective, Objective, Assessment, Plan of semidependently perfusion, injected alone or in combination with other anti-tumor drugs or as a palliative treatment, or as an adjunct to surgical treatment, with the method of preparation - 50 mg / kg - to lower limbs and the pelvic organs, 35 mg / kg - for the upper extremities, patients with excess body Galveston Orientation and Amnesia Test and previous treatment in cases of semidependently drugs and radiation therapy, recommended to prescribe smaller semidependently Daktolu. Indications for use of drugs: soft tissue sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid cancer, mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, ovarian cancer, body uterus, cervix, Vilmsa tumor, Ewing's sarcoma, neuroblastoma, embryonal rhabdomyosarcoma, prostate cancer, h.leykoz, multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. "injections 1915 IU vial. Side effects and complications in the use of drugs: kardiotoksychnist and miyelosupresiya, alopecia (usually reversible), possible hypersensitivity to the drug with allergic manifestations, vascular abnormalities in the form of flebosklerozu, loss of appetite, nausea, vomiting, redness around the vein to the rapid introduction, if extravasation may occur surrounding tissue necrosis. The main pharmaco-therapeutic action:.