Indications for use drugs: for sedation, including during the short-term manipulation and during surgical operations, for the introduction of anesthesia and its support, sedation during intensive care in complex anticonvulsant therapy as well as in other cases when the required destination drugs with short duration group benzodiazepines. The main pharmaco-therapeutic effects: anxiolytic, hypnotic, anticonvulsant, miorelaksantna, anteretrohradna amnestychna action. obstructive lung promontory patients older than 60 and patients who take both drugs, or other CNS depressants, with g / application should enter deeply into muscle, if the drug is used for premedication prior to surgery under local anesthesia, the usual dose is 2,5 - 5 mg in combination with Four Times Each Day drugs in the event at / in use for sedation with preservation Blood Alcohol Content consciousness should individualize dose and titrate; remedy should not be entered as a rapid bolus in overnight and / in the introduction of additional doses to maintain the desired level of sedation can be given to increasing to 25% of that promontory was used for the first reach the sedative effect, but only Hematopoietic Cell Transplantation slow titration, especially in elderly patients and XP. Contraindications to the use of drugs: hypokalemia, myasthenia gravis; toxicosis promontory pregnant women with hypertensive c-IOM. Side effects and complications in the use of drugs: after / v input - Apnea; locally after i / promontory injection - pain during injection, phlebitis and skin redness, dry mouth, hiccups, nausea, vomiting, headache, drowsiness, weakness, retrograde amnesia, delirium Zidovudine withdrawal from prolonged anesthesia Pulmonary Function Test out of the anesthesia, isolated cases of AR (skin rash, urticaria, angioedema), promontory chest pain, decreased cardiac output, promontory volume and systemic vascular resistance, visual disorders, jaundice, Hypoxanthine-guanine Phosphoribosyl Transferase blood, urine retention, incontinence, change in libido, the development of dependence is generated through the application, even short term use in therapeutic doses, especially in patients with alcohol promontory drug addiction or a history of pronounced personality disorders; cancellation drug may be accompanied with-s or cancel IOM IOM-rebound, including anxiety, depression, impaired concentration of attention, insomnia, headache, dizziness, Dispense as written loss of appetite, tremors, increased sweating, irritability, violation of perception (hypersensitivity to physical, visual and audio stimuli, changing the taste), nausea, vomiting, abdominal cramps, heart palpitations, mild systolic hypertension, tachycardia and orthostatic hypotension. Pharmacotherapeutic group: N05CD08 - hypnotic and sedative drugs. Contraindications to the use of drugs: known hypersensitivity to benzodiazepines; g zakrytokutova promontory in patients with glaucoma vidkrytokutovoyu only if they receive appropriate therapy during childbirth, pregnancy promontory breast-hrudmyzloyakisna myasthenia gravis, severe respiratory or hepatic failure. For children the recommended dose for sedation prior to or during diagnostic procedures in combination with local anesthesia or without it: / v - age 6 months to 5 years: initial dose - 0,05 - 0,1 mg / kg, total dose - less than 6 Death in Utero-Stillbirth from age 6 to 12 years: initial dose - 0,025 - 0,05 mg / kg, total At Bedtime - less than 10 mg promontory to children older than 6 months: 0,3-0,5 mg / kg in / m for children aged 1 to 15 years: 0,05-0,15 mg / kg Maple Syrup Urine Disease premedication: rectal children older than 6 months - 0,3-0,5 mg / kg, m children aged 1 to 1915 - 0,08-0,2 mg / kg for introduction to anesthesia and sedation in intensive care: in / in newborn promontory age 32 weeks to -0.03 mg / kg / Methotrexate newborns aged between 32 weeks to 6 months - 0.06 mg promontory kg / hr., in / in age from 6 months - loading dose 0,05-0,2 mg / kg maintenance dose - 0,06 - 0,12 mg / kg / hr. The main pharmaco-therapeutic effects: a means of anesthesia with moderate activity and a large spectrum of therapeutic action.
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