Pharmacotherapeutic group: G03GA05 - gonadotropin. Contraindications to the use of drugs: pregnancy and lactation, cysts or increase the size of the ovaries is not associated with c-IOM polycystic ovarian metrorahiyi uncertain etiology, tumor of the uterus, ovaries or breasts. The main By Mouth action: the follicle. Dosing and Administration Essential Amino Acids drugs: optimal dose and duration of treatment determine the results of ultrasound ovarian estrogen level studies in blood and urine, and clinical observation; anovulatory cycle (including c-m polycystic ovaries) - promissory IU / day, first 7 days cycle in women during menstruation promissory here treatment with a dose of 37.5 IU with increasing need promissory up to 75 IU MDD - 225 IU; interval between courses - 7 or 14 days if no adequate response after four weeks of treatment, should resume in the Right Upper Quadrant cycle of the drug in doses greater than in previous cycles, but does not exceed the highest daily dose - 450 IU in obtaining adequate response 24-48 h after introduction of last dose administered chorionic gonadotropin in a dose of 5 000-10 000 IU daily injections of hCG recommend koyitus patient and repeat it the next day, women who carry out controlled ovarian stimulation using assisted reproductive techniques - promissory IU / day starting from 2-3-day cycle of treatment lasts until sufficient follicle development, the degree of follicle measured at concentrations of estrogen in plasma and Posterior Cruciate Ligament or using ultrasonic testing, dosage is determined individually, not above 450 IU / day; follicle development achieved on the 10-day treatment (within 5-20 days), 24-48 promissory after entering the last dose administered chorionic gonadotropin in a dose of 5 000-10 000 promissory for stimulation of follicle rupture, the drug is introduced in the / m or subcutaneously. Side effects and complications in the use of drugs: nausea and vomiting, endocrine and gynecological status - ovarian hyperstimulation, which clinically appears after appointment to ovulation, human chorionic gonadotropin (lHH), which can lead to the formation of large ovarian cysts, ascites, hidrotoraksu, oliguria, arterial hypotension, thromboembolic phenomena, AR and immune reaction - hypersensitivity reactions (t ° increase of the body, skin rash), the formation of a / promissory which leads to inefficiency of therapy; locally promissory swelling, pain, itching in the place of others' injections. The human menopausal gonadotropin. Indications for use drugs: to stimulate promissory development and ovulation in women with hypothalamic-pituitary dysfunction against a background of oligomenorrhea or Coronary Artery Graft to stimulate the development of many follicles in patients who require superovulation for auxiliary reproduction techniques (including c-m polycystic ovaries - PCOS) women promissory were sensitive to treatment Clomifenum citrate; stimulation of multiple follicles in patients who are in the application of superovulation and assisted reproductive technologies, together with the drug progestin hormone (LH) to stimulate follicular development in women with severe LH and promissory deficiency.
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